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Pro-inflammatory cytokines are released when the IL-6/soluble IL-6 receptor (sIL-6R) complex interacts with the gp130 protein, initiating a variety of intracellular signaling pathways, including Janus kinase (JAK)/signal transducer, transcription activation (STAT), and phosphatidylinositol 3-kinase (PI3K) [101]
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[DOI] [PubMed] [Google Scholar] 16.von Staden L
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