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Together with the documented presence of estrogen receptors in intestinal cells and their dysregulation in disease, these findings strongly suggest that estrogen signaling directly influences colonic physiology and pathology (10, 11)
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Stimulation of the vagus nerve (direct and/or via taVNS) provides an intriguing option to investigate the effect of stimulation on this integrative process since it can stimulate the nucleus tractus solitarii , and the interconnected limbic and cortical areas that belong to the central autonomic network in both rodents and humans [10,11,12,13,14]
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